Design and In vitro Evaluation of Branched Peptide Conjugates: Turning Nonspecific Cytotoxic Drugs into Tumor??Selective Agents

C Falciani, J Brunetti, C Pagliuca, S Menichetti…

文献索引：Falciani, Chiara; Brunetti, Jlenia; Pagliuca, Chiara; Menichetti, Stefano; Vitellozzi, Lucia; Lelli, Barbara; Pini, Alessandro; Bracci, Luisa ChemMedChem, 2010 , vol. 5, # 4 p. 567 - 574

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被引用次数: 21

摘要

Abstract The use of peptide receptors as targets for tumor-selective therapies was envisaged years ago with the findings that receptors for different endogenous regulatory peptides are overexpressed in several primary and metastatic human tumors, and can be used as tumor antigens. Branched peptides can retain or even increase, through multivalent binding, the biological activity of a peptide and are very resistant to proteolysis, thus having a markedly ...