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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Phencyclidine-like effects of tetrahydroisoquinolines and related compounds

NM Gray, BK Cheng, SJ Mick, CM Lair…

文献索引：Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248

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被引用次数: 62

摘要

A series of 1, 2, 3, 4-tetrahydroisoquinolines, tetrahydrothieno [2, 3-~] pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-l-[l-(2-thienyl) piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and u receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the ...

Thieno[2,3-c]pyridine, 4,5-dihydro-7-methyl- (5CI)结构式

Thieno[2,3-c]py...

~%

7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine结构式

7-methyl-4,5,6,...

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3-(2-CHLOROETHYL)THIOPHENE结构式

3-(2-CHLOROETHY...

~%

7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine结构式

7-methyl-4,5,6,...

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对氟苯甲酰氯结构式

对氟苯甲酰氯

β-苯乙胺结构式

~87%

N-(4-氟苯甲酰基)-苯基乙胺结构式

N-(4-氟苯甲酰基)-苯基乙胺

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β-苯乙胺结构式

~%

1-cyclohexyl-3,4-dihydroisoquinoline结构式

1-cyclohexyl-3,...

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环己甲酰氯结构式

环己甲酰氯

~%

1-cyclohexyl-3,4-dihydroisoquinoline结构式

1-cyclohexyl-3,...

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对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

~%

1-(4'-METHOXY)-PHENYL-3,4-DIHYDRO-ISOQUINOLINE结构式

1-(4'-METHOXY)-...

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β-苯乙胺结构式

~%

1-(4'-METHOXY)-PHENYL-3,4-DIHYDRO-ISOQUINOLINE结构式

1-(4'-METHOXY)-...

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1-(4'-METHOXY)-PHENYL-3,4-DIHYDRO-ISOQUINOLINE结构式

1-(4'-METHOXY)-...

~%

1-(4-甲氧基苯基)-1,2,3,4-四氢异喹啉结构式

1-(4-甲氧基苯基)-1,2...

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β-溴苯乙烷结构式

β-溴苯乙烷

~%

Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)- (9CI)结构式

Isoquinoline, 1...

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4-methoxy-N-phenethyl-benzamide结构式

4-methoxy-N-phe...

~%

1-(4-甲氧基苯基)-1,2,3,4-四氢异喹啉结构式

1-(4-甲氧基苯基)-1,2...

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对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

~%

1-(4-甲氧基苯基)-1,2,3,4-四氢异喹啉结构式

1-(4-甲氧基苯基)-1,2...

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β-苯乙胺结构式

~%

1-(4-甲氧基苯基)-1,2,3,4-四氢异喹啉结构式

1-(4-甲氧基苯基)-1,2...

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1,3-dimethyl-3,4-dihydroisoquinoline结构式

1,3-dimethyl-3,...

~%

1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline结构式

1,3-dimethyl-1,...

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1-苯基-2-丙醇结构式

1-苯基-2-丙醇

~%

1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline结构式

1,3-dimethyl-1,...

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2-氯丙基苯结构式

~%

1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline结构式

1,3-dimethyl-1,...

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4-氯苯甲酰氯结构式

4-氯苯甲酰氯

β-苯乙胺结构式

~86%

Benzamide,4-chloro-N-(2-phenylethyl)结构式

Benzamide,4-chl...

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对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

β-苯乙胺结构式

~89%

4-methoxy-N-phenethyl-benzamide结构式

4-methoxy-N-phe...

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β-苯乙胺结构式

异戊酰氯结构式

~96%

Butanamide, 3-Methyl-N-(2-phenylethyl)结构式

Butanamide, 3-M...

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苯乙酸结构式

~%

1-benzyl-3,4-dihydroisoquinoline结构式

1-benzyl-3,4-di...

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硫酸二甲酯结构式

硫酸二甲酯

1-苯基-1,2,3,4-四氢异喹啉结构式

1-苯基-1,2,3,4-四氢异喹啉

~65%

2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline结构式

2-methyl-1-phen...

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1-苯基-3,4-二氢异喹啉结构式

1-苯基-3,4-二氢异喹啉

~%

2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline结构式

2-methyl-1-phen...

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N-苯乙基-苯甲酰胺结构式

N-苯乙基-苯甲酰胺

~%

2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline结构式

2-methyl-1-phen...

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苯甲酰氯结构式

~%

2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline结构式

2-methyl-1-phen...

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β-苯乙胺结构式

~%

2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline结构式

2-methyl-1-phen...

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β-苯乙胺结构式

~%

1-(2-methylpropyl)-3,4-dihydroisoquinoline结构式

1-(2-methylprop...

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异戊酰氯结构式

~%

1-(2-methylpropyl)-3,4-dihydroisoquinoline结构式

1-(2-methylprop...

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Butanamide, 3-Methyl-N-(2-phenylethyl)结构式

Butanamide, 3-M...

~%

1-(2-methylpropyl)-3,4-dihydroisoquinoline结构式

1-(2-methylprop...

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β-苯乙胺结构式

环己甲酰氯结构式

环己甲酰氯

~98%

N-(2-phenylethyl)cyclohexanecarboxamide结构式

N-(2-phenylethy...

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β-苯乙胺结构式

~%

1-环己基-1,2,3,4-四氢异喹啉结构式

1-环己基-1,2,3,4-四氢异喹啉

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环己甲酰氯结构式

环己甲酰氯

~%

1-环己基-1,2,3,4-四氢异喹啉结构式

1-环己基-1,2,3,4-四氢异喹啉

查看详情

1-苯基-2-丙醇结构式

1-苯基-2-丙醇

~%

1,3-dimethyl-3,4-dihydroisoquinoline结构式

1,3-dimethyl-3,...

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2-氯丙基苯结构式

乙腈结构式

~%

1,3-dimethyl-3,4-dihydroisoquinoline结构式

1,3-dimethyl-3,...

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N-(2-phenylethyl)cyclohexanimine结构式

N-(2-phenylethy...

~49%

1,1-pentamethylenetetrahydroisoquinoline结构式

1,1-pentamethyl...

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环己酮结构式

~%

1,1-pentamethylenetetrahydroisoquinoline结构式

1,1-pentamethyl...

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β-苯乙胺结构式

~%

1,1-pentamethylenetetrahydroisoquinoline结构式

1,1-pentamethyl...

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环己酮结构式

β-苯乙胺结构式

~95%

N-(2-phenylethyl)cyclohexanimine结构式

N-(2-phenylethy...

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A synthesis of heteroaromatic analogues of 1-methyl-1, 2, 3,...

[Horiguchi, Yoshie; Ogawa, Keita; Saitoh, Toshiaki; Sano, Takehiro Chemical and pharmaceutical bulletin, 2004 , vol. 52, # 2 p. 214 - 220]

A synthesis of heteroaromatic analogues of 1-methyl-1, 2, 3,...

[Horiguchi, Yoshie; Ogawa, Keita; Saitoh, Toshiaki; Sano, Takehiro Chemical and pharmaceutical bulletin, 2004 , vol. 52, # 2 p. 214 - 220]

A synthesis of heteroaromatic analogues of 1-methyl-1, 2, 3,...

[Horiguchi, Yoshie; Ogawa, Keita; Saitoh, Toshiaki; Sano, Takehiro Chemical and pharmaceutical bulletin, 2004 , vol. 52, # 2 p. 214 - 220]

A synthesis of heteroaromatic analogues of 1-methyl-1, 2, 3,...

[Horiguchi, Yoshie; Ogawa, Keita; Saitoh, Toshiaki; Sano, Takehiro Chemical and pharmaceutical bulletin, 2004 , vol. 52, # 2 p. 214 - 220]

A synthesis of heteroaromatic analogues of 1-methyl-1, 2, 3,...

[Horiguchi, Yoshie; Ogawa, Keita; Saitoh, Toshiaki; Sano, Takehiro Chemical and pharmaceutical bulletin, 2004 , vol. 52, # 2 p. 214 - 220]