Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

VR Rao, P Muthenna, G Shankaraiah…

文献索引：European Journal of Medicinal Chemistry, , vol. 57, p. 344 - 361

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被引用次数: 32

摘要

... European Journal of Medicinal Chemistry. ... Two chemical classes of ALR2 inhibitors (ARI) have also been tested under Phase II clinical trials (Fig ... Our initial medicinal chemistry efforts around the lead molecule, piplartine (1) demonstrated by Michael addition reaction with various ...