An alternative total synthesis of (−)-galanthamine (1) hydrobromide, employing ecofriendly amidation, oxidative coupling, and classical resolution strategies is accomplished. ... An alternative total synthesis of (−)-galanthamine (1) hydrobromide, employing ecofriendly amidation, oxidative coupling, and classical resolution strategies is accomplished. ... Galanthamine 1, active against the acetylcholinesterase enzyme that increases postsynaptic membrane susceptibility to ...