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Synthesis and biological evaluation of novel curcumin analogues as anti-inflammatory, anti-cancer and anti-oxidant agents

BP Bandgar, BS Hote, SS Jalde, RN Gacche

文献索引:Bandgar, Babasaheb P.; Hote, Baliram S.; Jalde, Shivkumar S.; Gacche, Rajesh N. Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3006 - 3014

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被引用次数: 4

摘要

Abstract A series of novel curcumin analogues 5a–m were synthesized by Claisen-Schmidt condensation of various aromatic and heteroaromatic amides of 3-aminoactophenones 4a– m with 3-bromo-2, 4, 6-trimethoxybenzaldehyde and characterized by IR, 1 H NMR and mass spectroscopic analysis and were evaluated for anti-inflammatory, anti-cancer and anti- oxidant activity. Out of the 13 synthesized compounds, compounds 5f, 5j and 5m were ...