Abstract A series of novel curcumin analogues 5a–m were synthesized by Claisen-Schmidt condensation of various aromatic and heteroaromatic amides of 3-aminoactophenones 4a– m with 3-bromo-2, 4, 6-trimethoxybenzaldehyde and characterized by IR, 1 H NMR and mass spectroscopic analysis and were evaluated for anti-inflammatory, anti-cancer and anti- oxidant activity. Out of the 13 synthesized compounds, compounds 5f, 5j and 5m were ...