Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs

…, AW Nicholas, G Manikumar, C Tele…

文献索引：Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700

全文：HTML全文

被引用次数: 181

摘要

A large number of camptothecin (CPT) analogs have been prepared in the 20S, 20RS, and 20R configurations with a number of ring A substituents. Topoisomerase I (TI) inhibition data (ICw) have been obtained by standard procedures. In general, substitution at the 9 or 10 positions with amino, halogeno, or hydroxyl groups in compounds with 20s configuration results in compounds with enhanced TI inhibition. Compounds in the 20RS configuration ...