Tetrahedron letters

Direct ni mediated synthesis of ketones from acyl bromides and grignard reagents

C Malanga, LA Aronica, L Lardicci

文献索引：Malanga, Corrado; Aronica, Laura A.; Lardicci, Luciano Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9185 - 9188

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被引用次数: 24

摘要

a catalytic amount of NidppeCl2 converts an acyl bromide directly into ketones at 0° C in THF in the presence of a Grignard reagent. The described procedure represents a useful way to afford dialkyl, diaryl or alkyl aryl ketones as well as 1, 2-diketones. In the adopted reaction conditions double bonds, esters and ketones are unaffected.