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Tetrahedron

New ketone homoenolate anion equivalents derived from (alkenyl) pentamethyl phosphoric triamides

C Grison, A Thomas, F Coutrot, P Coutrot

文献索引:Grison, Claude; Thomas, Antoine; Coutrot, Frederic; Coutrot, Philippe Tetrahedron, 2003 , vol. 59, # 12 p. 2101 - 2123

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被引用次数: 11

摘要

Lithiated ambident anions derived from (1-alkyl-2-propenyl)-or (1-phenyl-2-propenyl)- pentamethyl phosphoric triamides undergo regioselectively γ-reaction with various alkylating reagents and isobutyraldehyde. Further hydrolysis of adducts releases the ketone under acid conditions. Number of synthetic applications clearly show the ketone homoenolate behaviour of these new carbanions.

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