Antiviral activity of some. beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses

GD Diana, UJ Salvador, ES Zalay…

文献索引：Diana; Salvador; Zalay; et al. Journal of Medicinal Chemistry, 1977 , vol. 20, # 6 p. 750 - 756

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被引用次数: 44

摘要

The discovery that 4-[3-ethyl-6-[(3, 4-methylenedioxy) phenyl]-3-hexenyl]-3, 5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure-activity study to establish the criteria for optimum activity. Modification of the bridge included removal of the ethyl group and reduction of the double bond. The heptanedione was replaced with hexanedione and pentanedione with a minimal effect. The effect of ...