The discovery that 4-[3-ethyl-6-[(3, 4-methylenedioxy) phenyl]-3-hexenyl]-3, 5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure-activity study to establish the criteria for optimum activity. Modification of the bridge included removal of the ethyl group and reduction of the double bond. The heptanedione was replaced with hexanedione and pentanedione with a minimal effect. The effect of ...
![4-[6-(4-hydroxyphenyl)hexyl]heptane-3,5-dione Structure](https://image.chemsrc.com/caspic/442/52122-46-0.png)