Synthesis and CNS depressant activity of some novel 3-[5-substituted 1, 3, 4-thiadiazole-2-yl]-2-styryl quinazoline-4 (3H)-ones

V Jatav, P Mishra, S Kashaw, JP Stables

文献索引：Jatav, Varsha; Mishra, Pradeep; Kashaw, Sushil; Stables European Journal of Medicinal Chemistry, 2008 , vol. 43, # 1 p. 135 - 141

全文：HTML全文

被引用次数: 141

摘要

A series of novel 3-[5-substituted phenyl-1, 3, 4-thiadiazole-2-yl]-2-styryl quinazoline-4 (3H)- ones were synthesized and evaluated for anticonvulsant, sedative-hypnotic and CNS depressant activities. After ip injection to mice at doses of 30, 100, and 300mg/kg body weight 2-styrylquinazolin-4 (3H)-one derivatives were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) ...