A series of novel 3-[5-substituted phenyl-1, 3, 4-thiadiazole-2-yl]-2-styryl quinazoline-4 (3H)- ones were synthesized and evaluated for anticonvulsant, sedative-hypnotic and CNS depressant activities. After ip injection to mice at doses of 30, 100, and 300mg/kg body weight 2-styrylquinazolin-4 (3H)-one derivatives were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) ...
