Efficient synthesis of a highly selective NPY-5 receptor antagonist: A drug candidate for the treatment of obesity

T Itoh, S Kato, N Nonoyama, T Wada…

文献索引：Organic Process Research and Development, , vol. 10, # 4 p. 822 - 828

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被引用次数: 11

摘要

... Inc., Rahway, New Jersey 07065, USA. Org. Process Res. Dev. ... We found that both NBS and DBH were unstable in THF, DMSO, DME, dioxane, NMP, and various aqueous/organic systems. ... While this procedure was convenient and scalable, it was still not optimal. ...