Efficient synthesis of a highly selective NPY-5 receptor antagonist: A drug candidate for the treatment of obesity

T Itoh, S Kato, N Nonoyama, T Wada…

Index: Organic Process Research and Development, , vol. 10, # 4 p. 822 - 828

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Citation Number: 11

Abstract

... Inc., Rahway, New Jersey 07065, USA. Org. Process Res. Dev. ... We found that both NBS and DBH were unstable in THF, DMSO, DME, dioxane, NMP, and various aqueous/organic systems. ... While this procedure was convenient and scalable, it was still not optimal. ...