Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

H Serizawa, K Aikawa, K Mikami

文献索引：Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17692 - 17697

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被引用次数: 33

摘要

Trifluoromethyl compounds have attracted much attention in the pharmaceutical and agrochemical industries due to the unique properties of the trifluoromethyl group.[1, 2] Various synthetic methods for such compounds have so far been developed by the use of trifluoromethyl organometallic (MCF3) reagents.[3] However, hard lithium and magnesium cations cannot be employed for such reagents, because these MCF3 reagents are ...