Tetrahedron

Site-specific incorporation of non-natural residues into peptides: effect of residue structure on suppression and translation efficiencies

JD Bain, DA Wacker, EE Kuo, AR Chamberlin

文献索引：Bain; Wacker, Dean A.; Kuo, Eric E.; Chamberlin, A. Richard Tetrahedron, 1991 , vol. 47, # 14-15 p. 2389 - 2400

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被引用次数: 75

摘要

A systematic survey of the structural requirements for biosynthetic incorporation of non- natural residues into a polypeptide is presented. Relative translation efficiencies for a series of 12 semi-synthetic acylated suppressor tRNAs ranged from 0 to 91% depending on the structure of the residue incorporated. A systematic survey of the structural requirements for biosynthetic incorporation of non-natural residues into a polypeptide is presented. ...