Organic Process Research & Development

Synthesis of enantiopure Fmoc-α-methylvaline

L Shu, P Wang

文献索引：Shu, Lianhe; Wang, Ping Organic Process Research and Development, 2008 , vol. 12, # 2 p. 298 - 300

全文：HTML全文

被引用次数: 7

摘要

An efficient synthesis of enantiopure Fmoc-α-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved using a chiral amine,(S)-1, 2, 3, 4-tetrahydro-1-naphthylamine to give the desired, enantiopure S- isomer in 23% overall yield.