2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1, 2, 4] triazolo [1, 5-b][1, 2, 4] benzothiadiazine conjugates as potential mitochondrial apoptotic inducers

…, F Sultana, T Kaur, G Chashoo, N Suri, I Sehar…

文献索引：Kamal, Ahmed; Srikanth; Naseer Ahmed Khan; Ashraf, Md.; Kashi Reddy; Sultana, Farheen; Kaur, Tandeep; Chashoo, Gousia; Suri, Nitasha; Sehar, Irum; Wani, Zahoor A.; Saxena, Arpita; Sharma, Parduman R.; Bhushan, Shashi; Mondhe, Dilip M.; Saxena, Ajit K. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 23 p. 7136 - 7150

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被引用次数: 13

摘要

A series of N-(2-anilino-pyridyl) linked 2-amino benzothiazoles (4a–n) and [1, 2, 4] triazolo [1, 5-b] benzothiadiazine conjugates (5a–j) have been designed, synthesized and evaluated for their antiproliferative activity. Some of these compounds (4h–k, 4n, and 5e) have exhibited potent cytotoxicity specifically against human leukemia HL-60 cell lines with IC50 values in the range of 0.08–0.70 μM. All these compounds were tested for their effects on ...