2-[(4-Chlorophenyl)amino]nicotinic acid

• 常用名: 2-[(4-Chlorophenyl)amino]nicotinic acid
• 英文名: DHODH-IN-17
• CAS号: 16344-26-6
• 分子量: 248.67
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₉ClN₂O₂
• 熔点: N/A
• 闪点: N/A

用途

DHODH-IN-17是一种2-苯胺基烟酸,是一种人体DHODH抑制剂(IC50=0.40μM)。DHODH-IN-17可用于急性髓系白血病(AML)的研究[1]。

2-[(4-Chlorophenyl)amino]nicotinic acid名称

• 中文名: 2-[(4-氯苯基)氨基]-3-吡啶羧酸
• 英文名: 2-(4-chloroanilino)pyridine-3-carboxylic acid

2-[(4-Chlorophenyl)amino]nicotinic acid生物活性

• 描述: DHODH-IN-17是一种2-苯胺基烟酸,是一种人体DHODH抑制剂(IC50=0.40μM)。DHODH-IN-17可用于急性髓系白血病(AML)的研究[1]。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  IC50: 0.4 μM (DHODH)[1]

• 体外研究: DHODH-IN-17是一种2-苯胺基烟酸,是一种人体DHODH抑制剂,IC50值为0.40μM[1]。
• 参考文献:

  [1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7(12):1112-1117.

2-[(4-Chlorophenyl)amino]nicotinic acid物理化学性质

• 分子式: C₁₂H₉ClN₂O₂
• 分子量: 248.67
• 精确质量: 248.03500
• PSA: 62.22000
• LogP: 3.24980
• InChIKey: YEXIXVLEDGNAKM-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccnc1Nc1ccc(Cl)cc1
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

2-[(4-Chlorophenyl)amino]nicotinic acid靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Dose response of compounds that promote myeloid differentiation with HOXA9ER cells wi... 来源：NMMLSC External Id：UNMCMD_HOXA9_MYELOIDDIFFERENTIATION_HOXA9ER_SAR01

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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2-[(4-Chlorophenyl)amino]nicotinic acid英文别名

• 2-[(4-chlorophenyl)amino]-3-pyridinecarboxylic acid
• HMS2655G09
• 2-(4-chloro-anilino)-nicotinic acid
• 2-(4-Chloro-phenylamino)-nicotinic acid
• 2-(p-Chloranilino)-nicotinsaeure
• 2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid