Practical, catalytic synthesis of anthranilic acids

D Valentine Jr, JW Tilley…

文献索引：Valentine, Donald; Tilley, Jefferson W.; LeMahieu, Ronald A. Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4614 - 4617

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被引用次数: 43

摘要

General conditions: 3 atm of CO; 110-130" C; Bu3N (1.1 equiv); H, O (ca. 3 equiv); Pd (PPh,),(Cl),+ 2% PPh,. Recrystallized yields. Catalyst precipitated. d Catalyst was Pd (P (o- CH, C, H,),), Cl,. use of sterically hindered ligands [eg, tris (2-toly1) phosphine] in place of triphenylphosphine or use of expensive 2-iodoanilines as substrates. In the presence of iodide, phosphines are not needed to stabilize the palladium catalysts. Both approaches ...