ACS medicinal chemistry letters

Preparative microfluidic electrosynthesis of drug metabolites

R Stalder, GP Roth

文献索引：Stalder, Romain; Roth, Gregory P. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123

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被引用次数: 28

摘要

In vivo, a drug molecule undergoes its first chemical transformation within the liver via CYP450-catalyzed oxidation. The chemical outcome of the first pass hepatic oxidation is key information to any drug development process. Electrochemistry can be used to simulate ...