Cyanides??Free Cyanation of Aryl Halides using Formamide

…, PJ Tambade, KD Bhatte, BM Bhanage

文献索引：Sawant, Dinesh N.; Wagh, Yogesh S.; Tambade, Pawan J.; Bhatte, Kushal D.; Bhanage, Bhalchandra M. Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 781 - 787

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被引用次数: 40

摘要

Abstract A novel method for cyanation of aryl halides using formamide as a non-toxic cyanide source is reported. It is a single-step, solvent-free method wherein formamide itself acts as solvent as well as source of cyanide in the presence of phosphorus oxychloride and palladium acetate/xantphos catalyst. Aryl iodides as well as aryl bromides provided moderate to excellent yields of up to 93%.