Tetrahedron letters

Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

SV Narina, A Sudalai

文献索引：Narina, Srinivasarao V.; Sudalai, Arumugam Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6799 - 6802

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被引用次数: 29

摘要

An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.