依哌唑胺

• 常用名: 依哌唑胺
• 英文名: Eperezolid
• CAS号: 165800-04-4
• 分子量: 394.39700
• 密度: 1.37g/cm3
• 沸点: 701.2ºC at 760 mmHg
• 分子式: C₁₈H₂₃FN₄O₅
• 熔点: N/A
• 闪点: 377.9ºC

依哌唑胺用途

Eperezolid(PNU-100592)是恶唑烷酮类抗生素，有很好的体外抑制性。

依哌唑胺名称

• 中文名: N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷基]甲基]-乙酰胺
• 英文名: N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

依哌唑胺生物活性

• 描述: Eperezolid(PNU-100592)是恶唑烷酮类抗生素,有很好的体外抑制性。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Rybak MJ, et al. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus f

  [2]. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31.

  [3]. Zhou CC, et al. 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes. Antimicrob Agents Chemother. 2002 Mar;46(3):625-9.

依哌唑胺物理化学性质

• 密度: 1.37g/cm3
• 沸点: 701.2ºC at 760 mmHg
• 分子式: C₁₈H₂₃FN₄O₅
• 分子量: 394.39700
• 闪点: 377.9ºC
• 精确质量: 394.16500
• PSA: 102.42000
• LogP: 0.38670
• InChIKey: SIMWTRCFFSTNMG-AWEZNQCLSA-N
• SMILES: CC(=O)NCC1CN(c2ccc(N3CCN(C(=O)CO)CC3)c(F)c2)C(=O)O1
• 蒸汽压: 1.22E-20mmHg at 25°C
• 折射率: 1.579
• 储存条件: 2-8℃

依哌唑胺安全信息

• 海关编码: 2934999090

依哌唑胺海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

依哌唑胺靶点实验

查看更多实验

实验名称：Minimum inhibitory concentration evaluated against enterococci species susceptible to... 来源：ChEMBL 靶标：Enterococcus External Id：CHEMBL678466

实验名称：Minimum inhibitory concentration evaluated against enterococci species resistant to v... 来源：ChEMBL 靶标：Enterococcus External Id：CHEMBL678465

实验名称：Inhibitory activity against Streptococcus pyogenes 来源：ChEMBL 靶标：Streptococcus pyogenes External Id：CHEMBL812367

实验名称：Compound was tested against Staphylococcus aureus UC9213 after po administration in m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL734983

实验名称：Harmonic mean apparent terminal disposition half-life [t1/2beta (h)] in Male Sprague-... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL635697

实验名称：Tmax value in Male Sprague-Dawley Rat at dose 25 (mg/kg po) [tmax (h)] 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL641000

实验名称：Minimum inhibitory concentration against Bacillus pumilus MTCC 1607 来源：ChEMBL 靶标：Bacillus pumilus External Id：CHEMBL857920

实验名称：Dose required to cure 50% of Staphylococcus aureus infected mice in the presence of v... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL841515

实验名称：Plasma clearance in Male Sprague-Dawley Rat (25 mg/kg po); ND denotes not reported 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL639098

实验名称：In vivo antibacterial activity against Enterococcus faecalis strain UC 12379 administ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL717623

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依哌唑胺英文别名

• Eperezolid