Carbohydrate Research 2010-09-23

Activation of glycosyl trichloroacetimidates with perchloric acid on silica (HClO(4)-SiO(2)) provides enhanced alpha-selectivity.

Olaf R Ludek, Wenlu Gu, Jeffrey C Gildersleeve

文献索引：Carbohydr. Res. 345(14) , 2074-8, (2010)

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摘要

Obtaining high stereoselectivity in glycosylation reactions is often challenging in the absence of neighboring group participation. In this study, we demonstrate that activation of glycosyl trichloroacetimidate donors with immobilized perchloric acid on silica (HClO(4)-SiO(2)) provides higher alpha-selectivity than trimethylsilyl triflate (TMSOTf) for reactions that do not involve neighboring group participation.Published by Elsevier Ltd.