Displacement of the amino group of 7-amino [1, 2, 5] thiadiazolo [3, 4-d] pyrimidine (I) by secondary amines was shown to occur with the formation of 7-(disubstituted amino)[1, 2, 5] thiadiazolo [3, 4-d] pyrimidines(V-VIII). Primary amines were likewise shown to effect displacement of the amino group, but cleavage of the pyrimidine ring to a 1, 2, 5-thiadiazole may ensue. The structure of the amino-group exchange product from I and butylamine ...