Rapid Enabling of Negishi Couplings for a Pair of mGluR5 Negative Allosteric Modulators

A Gontcharov, JR Dunetz

文献索引：Liu, Zhichang; Xiang, Jiannan Organic Process Research and Development, 2006 , vol. 10, # 2 p. 285 - 288

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被引用次数: 1

摘要

... and at the iodide via transition-metal-catalyzed cross-coupling (Scheme 1). The initial procedure for chloride ... Figure 3. Revised semibatch process for Negishi coupling with slow addition of 7a ... 1) nonbasic impurities (eg, trace 5, PPh 3 ) would be retained in the organic layer, and ...