Discovery of BMS-846372, a potent and orally active human CGRP receptor antagonist for the treatment of migraine
…, M Gulianello, Y Huang, W Kostich…
文献索引：Gray, George W.; Hird, Michael; Lacey, David; Toyne, Kenneth J. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 2041 - 2054
... Select a Journal or Book ... side effects associated with the use of triptans.(14) While this compound effectively demonstrated the first clinical proof of concept, its route of administration and chemical instability precluded ... (j) NaH, THF; rt, 18 h (46%), then chiral separation. ...
