e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Discovery of BMS-846372, a potent and orally active human CGRP receptor antagonist for the treatment of migraine

…, M Gulianello, Y Huang, W Kostich…

Index: Gray, George W.; Hird, Michael; Lacey, David; Toyne, Kenneth J. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 2041 - 2054

Full Text: HTML

Citation Number: 15

Abstract

... Select a Journal or Book ... side effects associated with the use of triptans.(14) While this compound effectively demonstrated the first clinical proof of concept, its route of administration and chemical instability precluded ... (j) NaH, THF; rt, 18 h (46%), then chiral separation. ...

Heptanal Structure

~%

2,3-DIFLUORO-4-HEPTYL-4''-PENTYLTERPHENYL Structure

2,3-DIFLUORO-4-...

1,2-Difluorobenzene Structure

1,2-Difluorobenzene

~%

2,3-DIFLUORO-4-HEPTYL-4''-PENTYLTERPHENYL Structure

2,3-DIFLUORO-4-...

4'-Bromononanophenone Structure

4'-Bromononanop...

~40%

1-Bromo-4-nonylbenzene Structure

1-Bromo-4-nonyl...

Bromobenzene Structure

~%

1-Bromo-4-nonylbenzene Structure

1-Bromo-4-nonyl...

Nonanoyl chloride Structure

Nonanoyl chloride

~%

1-Bromo-4-nonylbenzene Structure

1-Bromo-4-nonyl...

1-Bromohexane Structure

2,3-Difluorophenol Structure

2,3-Difluorophenol

~94%

1-Hexyloxy-2,3-difluorobenzene Structure

1-Hexyloxy-2,3-...

1,2-Difluorobenzene Structure

1,2-Difluorobenzene

~%

1-Hexyloxy-2,3-difluorobenzene Structure

1-Hexyloxy-2,3-...

Bromobenzene Structure

~%

2,3-difluoro-1,4-bis(4-pentylphenyl)benzene Structure

2,3-difluoro-1,...

p-Bromophenyl butyl ketone Structure

p-Bromophenyl b...

~%

2,3-difluoro-1,4-bis(4-pentylphenyl)benzene Structure

2,3-difluoro-1,...

Valeryl chloride Structure

Valeryl chloride

~%

2,3-difluoro-1,4-bis(4-pentylphenyl)benzene Structure

2,3-difluoro-1,...

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

~%

2,3-difluoro-1,4-bis(4-pentylphenyl)benzene Structure

2,3-difluoro-1,...

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

1,2-difluoro-3-(4-pentylphenyl)benzene Structure

1,2-difluoro-3-...

~%

2,3-difluoro-1,4-bis(4-pentylphenyl)benzene Structure

2,3-difluoro-1,...

Bromobenzene Structure

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

p-Bromophenyl butyl ketone Structure

p-Bromophenyl b...

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

1-Bromo-4-heptanoylbenzene Structure

1-Bromo-4-hepta...

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

Valeryl chloride Structure

Valeryl chloride

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

Heptanoyl chloride Structure

Heptanoyl chloride

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

p-Bromophenyl butyl ketone Structure

p-Bromophenyl b...

~79%

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

Bromobenzene Structure

~%

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

Valeryl chloride Structure

Valeryl chloride

~%

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

1-Bromo-4-heptanoylbenzene Structure

1-Bromo-4-hepta...

~56%

1-Bromo-4-heptylbenzene Structure

1-Bromo-4-hepty...

1-Bromo-4-pentylbenzene Structure

1-Bromo-4-penty...

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

1-Bromo-4-heptylbenzene Structure

1-Bromo-4-hepty...

1,2-difluoro-3-(4-pentylphenyl)benzene Structure

1,2-difluoro-3-...

~%

2,3-difluoro-1-(4-heptylphenyl)-4-(4-pentylphenyl)benzene Structure

2,3-difluoro-1-...

Bromobenzene Structure

Heptanoyl chloride Structure

Heptanoyl chloride

~99%

1-Bromo-4-heptanoylbenzene Structure

1-Bromo-4-hepta...