Journal of Pharmaceutical and Biomedical Analysis 2009-05-01

The stability of biapenem and structural identification of impurities in aqueous solution.

Ming Xia, Tai-Jun Hang, Fei Zhang, Xiao-Min Li, Xiang-Yang Xu

文献索引：J. Pharm. Biomed. Anal. 49(4) , 937-44, (2009)

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摘要

The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC-MS/MS. One dimeric impurity was obtained by reverse-phase preparative HPLC and characterized by LC-MS/MS and NMR. A possible degradation mechanism has been presented.