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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthese de dihydro-6, 7 5H-pyrimidino (5, 4-c) carbazoles et de 7H-pyrimidino (5, 4-c) carbazoles.

JC LANcELoT, JM GAzENGEL…

文献索引：Lancelot, Jean-Charles; Gazengel, Jean-Marie; Robba, Max Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2652 - 2661

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被引用次数: 11

摘要

The synthesis of 6, 7-dihydro-5H-pyrimidino [5, 4-c] carbazoles (3) was achieved by cyclisation of 1, 2, 3, 4-tetrahydrocarbazol-4-ones with triformamidomethane. The oxydation with potassium permanganate of 6, 7-dihydro-5H-pyrimidino [5, 4-c] carbazoles gave the 7H- pyrimidino [5, 4-c] carbazoles (4). The reactions of the pyrimidinocarbazoles (4a) and (4e) with lithium organic compounds afforded 4-substituted derivatives (6). The structure of the ...

对氯苯肼盐酸盐结构式

对氯苯肼盐酸盐

1,3-环己二酮结构式

1,3-环己二酮

~63%

6-chloro-1,2,3,9-tetrahydrocarbazol-4-one结构式

6-chloro-1,2,3,...

硫酸二乙酯结构式

硫酸二乙酯

1,2,3,4-四氢咔唑-4-酮结构式

1,2,3,4-四氢咔唑-4-酮

~89%

9-ethyl-2,3-dihydro-1H-carbazol-4-one结构式

9-ethyl-2,3-dih...

4-甲基苯肼盐酸盐结构式

4-甲基苯肼盐酸盐

1,3-环己二酮结构式

1,3-环己二酮

~67%

4H-Carbazol-4-one,1,2,3,9-tetrahydro-6-methyl-结构式

4H-Carbazol-4-o...

dihydro-6,7 chloro-10 5H-pyrimidino<5,4-c>carbazole结构式

dihydro-6,7 chl...

~53%

10-chloro-7H-pyrimido[5,4-c]carbazole结构式

10-chloro-7H-py...

5H-Pyrimido[5,4-c]carbazole, 10-fluoro-6,7-dihydro-结构式

5H-Pyrimido[5,4...

~68%

10-fluoro-7H-pyrimido[5,4-c]carbazole结构式

10-fluoro-7H-py...

5H-Pyrimido[5,4-c]carbazole, 9-chloro-6,7-dihydro-结构式

5H-Pyrimido[5,4...

~34%

9-chloro-7H-pyrimido[5,4-c]carbazole结构式

9-chloro-7H-pyr...

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-结构式

5H-Pyrimido[5,4...

~29%

7H-pyrimido[5,4-c]carbazole结构式

7H-pyrimido[5,4...

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-7-methyl-结构式

5H-Pyrimido[5,4...

~19%

7-methylpyrimido[5,4-c]carbazole结构式

7-methylpyrimid...

N,N',N''-甲基乙二甲醛甲酰胺结构式

N,N',N''-甲基乙二甲醛甲酰胺

6-chloro-9-methyl-2,3-dihydro-1H-carbazol-4-one结构式

6-chloro-9-meth...

~48%

5H-Pyrimido[5,4-c]carbazole, 10-chloro-6,7-dihydro-7-methyl-结构式

5H-Pyrimido[5,4...

1,2,3,9-四氢-9-甲基咔唑酮结构式

1,2,3,9-四氢-9-甲基咔唑酮

N,N',N''-甲基乙二甲醛甲酰胺结构式

N,N',N''-甲基乙二甲醛甲酰胺

~29%

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-7-methyl-结构式

5H-Pyrimido[5,4...

N,N',N''-甲基乙二甲醛甲酰胺结构式

N,N',N''-甲基乙二甲醛甲酰胺

7-chloro-1,2,3,9-tetrahydrocarbazol-4-one结构式

7-chloro-1,2,3,...

~34%

5H-Pyrimido[5,4-c]carbazole, 9-chloro-6,7-dihydro-结构式

5H-Pyrimido[5,4...

3-氯苯肼盐酸盐结构式

3-氯苯肼盐酸盐

1,3-环己二酮结构式

1,3-环己二酮

~51%

7-chloro-1,2,3,9-tetrahydrocarbazol-4-one结构式

7-chloro-1,2,3,...

dihydro-6,7 dichloro-8,10 5H-pyrimidino<5,4-c>carbazole结构式

dihydro-6,7 dic...

~51%

8,10-dichloro-7H-pyrimido[5,4-c]carbazole结构式

8,10-dichloro-7...

正溴丁烷结构式

7H-pyrimido[5,4-c]carbazole结构式

7H-pyrimido[5,4...

~55%

4-butyl-4,7-dihydro-1H-pyrimido[5,4-c]carbazole结构式

4-butyl-4,7-dih...

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-结构式

5H-Pyrimido[5,4...

~%

4-butyl-4,7-dihydro-1H-pyrimido[5,4-c]carbazole结构式

4-butyl-4,7-dih...

4-butyl-4,7-dihydro-1H-pyrimido[5,4-c]carbazole结构式

4-butyl-4,7-dih...

~59%

4-butyl-7H-pyrimido[5,4-c]carbazole结构式

4-butyl-7H-pyri...

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-结构式

5H-Pyrimido[5,4...

~%

4-butyl-7H-pyrimido[5,4-c]carbazole结构式

4-butyl-7H-pyri...

7H-pyrimido[5,4-c]carbazole结构式

7H-pyrimido[5,4...

~%

4-butyl-7H-pyrimido[5,4-c]carbazole结构式

4-butyl-7H-pyri...

2,4-二氯苯肼盐酸盐结构式

2,4-二氯苯肼盐酸盐

1,3-环己二酮结构式

1,3-环己二酮

~54%

6,8-dichloro-1,2,3,9-tetrahydrocarbazol-4-one结构式

6,8-dichloro-1,...

4H-Carbazol-4-one,1,2,3,9-tetrahydro-6-methyl-结构式

4H-Carbazol-4-o...

硫酸二甲酯结构式

硫酸二甲酯

~82%

6,9-dimethyl-2,3-dihydro-1H-carbazol-4-one结构式

6,9-dimethyl-2,...

4-甲基苯肼盐酸盐结构式

4-甲基苯肼盐酸盐

~%

6,9-dimethyl-2,3-dihydro-1H-carbazol-4-one结构式

6,9-dimethyl-2,...

1,3-环己二酮结构式

1,3-环己二酮

~%

6,9-dimethyl-2,3-dihydro-1H-carbazol-4-one结构式

6,9-dimethyl-2,...

正溴丁烷结构式

7-ethylpyrimido[5,4-c]carbazole结构式

7-ethylpyrimido...

~41%

4-butyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

dihydro-5,6 ethyl-7 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 eth...

~%

4-butyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

4-butyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

~49%

4-butyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

dihydro-5,6 ethyl-7 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 eth...

~%

4-butyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

7-ethylpyrimido[5,4-c]carbazole结构式

7-ethylpyrimido...

~%

4-butyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-butyl-7-ethyl...

N,N',N''-甲基乙二甲醛甲酰胺结构式

N,N',N''-甲基乙二甲醛甲酰胺

6-methoxy-1,2,3,9-tetrahydrocarbazol-4-one结构式

6-methoxy-1,2,3...

~6%

10-methoxy-6,7-dihydro-5H-pyrimido[5,4-c]carbazole结构式

10-methoxy-6,7-...

5H-Pyrimido[5,4-c]carbazole, 10-chloro-6,7-dihydro-7-methyl-结构式

5H-Pyrimido[5,4...

~30%

7H-Pyrimido[5,4-c]carbazole, 10-chloro-7-methyl-结构式

7H-Pyrimido[5,4...

6-chloro-1,2,3,9-tetrahydrocarbazol-4-one结构式

6-chloro-1,2,3,...

硫酸二甲酯结构式

硫酸二甲酯

~72%

6-chloro-9-methyl-2,3-dihydro-1H-carbazol-4-one结构式

6-chloro-9-meth...

对氯苯肼盐酸盐结构式

对氯苯肼盐酸盐

~%

6-chloro-9-methyl-2,3-dihydro-1H-carbazol-4-one结构式

6-chloro-9-meth...

1,3-环己二酮结构式

1,3-环己二酮

~%

6-chloro-9-methyl-2,3-dihydro-1H-carbazol-4-one结构式

6-chloro-9-meth...

环丙溴结构式

7-ethylpyrimido[5,4-c]carbazole结构式

7-ethylpyrimido...

~59%

4-cyclopropyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

dihydro-5,6 ethyl-7 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 eth...

~%

4-cyclopropyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

4-cyclopropyl-7-ethyl-1,4-dihydropyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

~60%

4-cyclopropyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

dihydro-5,6 ethyl-7 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 eth...

~%

4-cyclopropyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

7-ethylpyrimido[5,4-c]carbazole结构式

7-ethylpyrimido...

~%

4-cyclopropyl-7-ethylpyrimido[5,4-c]carbazole结构式

4-cyclopropyl-7...

4-甲氧基苯肼盐酸盐结构式

4-甲氧基苯肼盐酸盐

1,3-环己二酮结构式

1,3-环己二酮

~33%

6-methoxy-1,2,3,9-tetrahydrocarbazol-4-one结构式

6-methoxy-1,2,3...

dihydro-5,6 ethyl-7 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 eth...

~57%

7-ethylpyrimido[5,4-c]carbazole结构式

7-ethylpyrimido...

1,2,3,4-四氢咔唑-4-酮结构式

1,2,3,4-四氢咔唑-4-酮

N,N',N''-甲基乙二甲醛甲酰胺结构式

N,N',N''-甲基乙二甲醛甲酰胺

~54%

5H-Pyrimido[5,4-c]carbazole, 6,7-dihydro-结构式

5H-Pyrimido[5,4...

10-methoxy-6,7-dihydro-5H-pyrimido[5,4-c]carbazole结构式

10-methoxy-6,7-...

~31%

10-methoxy-7H-pyrimido[5,4-c]carbazole结构式

10-methoxy-7H-p...

dihydro-5,6 dimethyl-7,10 pyrimidino<5,4-c>carbazole结构式

dihydro-5,6 dim...

~31%

7,10-dimethylpyrimido[5,4-c]carbazole结构式

7,10-dimethylpy...

A mild and effective method to synthesize carbazolones by Cu...

[Yan, Shaoyu; Wu, Haihong; Wu, Nan; Jiang, Yongwen Synlett, 2007 , # 17 p. 2699 - 2702]

A mild and effective method to synthesize carbazolones by Cu...

[Yan, Shaoyu; Wu, Haihong; Wu, Nan; Jiang, Yongwen Synlett, 2007 , # 17 p. 2699 - 2702]

Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure...

[Li, Kexue; McGee, Lawrence R.; Fisher, Ben; Sudom, Athena; Liu, Jinsong; Rubenstein, Steven M.; Anwer, Mohmed K.; Cushing, Timothy D.; Shin, Youngsook; Ayres, Merrill; Lee, Fei; Eksterowicz, John; Faulder, Paul; Waszkowycz, Bohdan; Plotnikova, Olga; Farrelly, Ellyn; Xiao, Shou-Hua; Chen, Guoqing; Wang, Zhulun Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1238 - 1244]

Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure...

[Li, Kexue; McGee, Lawrence R.; Fisher, Ben; Sudom, Athena; Liu, Jinsong; Rubenstein, Steven M.; Anwer, Mohmed K.; Cushing, Timothy D.; Shin, Youngsook; Ayres, Merrill; Lee, Fei; Eksterowicz, John; Faulder, Paul; Waszkowycz, Bohdan; Plotnikova, Olga; Farrelly, Ellyn; Xiao, Shou-Hua; Chen, Guoqing; Wang, Zhulun Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1238 - 1244]