Organic letters

Synthesis of Imidazo [4, 5-b] pyridines and Imidazo [4, 5-b] pyrazines by Palladium Catalyzed Amidation of 2-Chloro-3-amino-heterocycles

AJ Rosenberg, J Zhao, DA Clark

文献索引：Rosenberg, Adam J.; Zhao, Jinbo; Clark, Daniel A. Organic Letters, 2012 , vol. 14, # 7 p. 1764 - 1767

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被引用次数: 22

摘要

A facile synthesis of imidazo [4, 5-b] pyridines and-pyrazines is described using a Pd- catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP.