Structural modification of sanguinarine and chelerythrine and their antibacterial activity

F Miao, XJ Yang, L Zhou, HJ Hu, F Zheng…

文献索引：Miao, Fang; Yang, Xin-Juan; Zhou, Le; Hu, Hai-Jun; Zheng, Feng; Ding, Xu-Dong; Sun, Dong-Mei; Zhou, Chun-Dong; Sun, Wei Natural Product Research, 2011 , vol. 25, # 9 p. 863 - 875

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被引用次数: 49

摘要

In this study, five derivatives of sanguinarine (1) and chelerythrine (2) were prepared, with 1 and 2 as starting materials, by reduction, oxidation and nucleophilic addition to the iminium bond C= N+. The structures of all compounds were elucidated on account of their MS, 1H- NMR and 13C-NMR data. The antibacterial activities of all compounds were screened, using Staphylococcus aureus, Escherichia coli, Aeromonas hydrophila and Pasteurella ...