Effect of Flavonol Derivatives on the Carrageenin??Induced Paw Edema in the Rat and Inhibition of Cyclooxygenase??1 and 5??Lipoxygenase in Vitro

…, W Werner, G Blaschke, W Kiefer, U Nowe…

文献索引：Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

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被引用次数: 23

摘要

Abstract Alkoxyflavonols were synthesized by the Algar-Flynn-Oyamada (AFO) cyclization of chalcones. Hydroxyflavonols were prepared by dealkylation of methoxyflavonols by refluxing in hydroiodic acid. The alkoxyflavonols 3-hydroxy-2-(2, 3, 4-trimethoxy-phenyl)-4H- chromen-4-one (6), 2-(4-ethoxyphenyl)-3-hydroxy-4H-chromen-4-one (7), 2-(4- butoxyphenyl)-3-hydroxy-4H-chromen-4-one (10), and 2-(3-n-butoxyphenyl)-3-hydroxy- ...