Tetrahedron Letters

Sulfonamide synthesis using N-hydroxybenzotriazole sulfonate: an alternative to pentafluorophenyl (PFP) and trichlorophenyl (TCP) esters of sulfonic acids

NB Palakurthy, B Mandal

文献索引：Palakurthy, Nani Babu; Mandal, Bhubaneswar Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7132 - 7134

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被引用次数: 13

摘要

The N-hydroxybenzotriazole (HOBt) sulfonate esters undergo amidation under ambient conditions in the presence of di-isopropylethyl amine. This method can be applied to varieties of amines including sterically hindered amino acid esters in less time with reasonably good yields. HOBt ester of sulfonic acids can be a replacement for pentafluorophenyl and trichlorophenyl ester as well as chloride moiety of sulfonyl chloride ...