The Journal of organic chemistry

Copper-catalyzed domino annulation approaches to the synthesis of benzoxazoles under microwave-accelerated and conventional thermal conditions

RD Viirre, G Evindar, RA Batey

文献索引：Viirre, Russell D.; Evindar, Ghotas; Batey, Robert A. Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3452 - 3459

全文：HTML全文

被引用次数: 199

摘要

Two domino annulation approaches for benzoxazole synthesis have been developed. In the first approach, copper-catalyzed intermolecular cross-coupling of 1, 2-dihaloarenes with primary amides initially forms the Ar− N bond of the benzoxazole ring, followed by copper- catalyzed intramolecular cyclization to form the Ar− O bond. Benzoxazoles were formed in good yields for the reaction of 1, 2-dibromobenzene, but the reaction was not ...