Organic letters

Iron-catalyzed intramolecular O-arylation: synthesis of 2-aryl benzoxazoles

J Bonnamour, C Bolm

文献索引：Bonnamour, Julien; Bolm, Carsten Organic Letters, 2008 , vol. 10, # 13 p. 2665 - 2667

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被引用次数: 146

摘要

A practical iron-catalyzed intramolecular O-arylation reaction and its application in the synthesis of benzoxazole derivatives, starting from the readily available 2-haloanilines, is presented. The key cyclization step involves the use of a combination of the cheap and environmentally friendly FeCl3 and 2, 2, 6, 6-tetramethyl-3, 5 heptanedione (TMHD) as the catalyst system.