Synthesis and in vitro evaluation of 2, 4-diamino-1, 3, 5-triazine derivatives as neuronal voltage-gated sodium channel blockers

X Ma, TY Poon, PTH Wong, WK Chui

文献索引：Ma, Xiang; Poon, Thong-Yuen; Wong, Peter Tsun Hon; Chui, Wai-Keung Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5644 - 5647

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被引用次数: 18

摘要

Neuronal sodium channels blockers interfere with ion flux and have been used for managing neuropathic pain, epilepsy, and cerebral ischemic disorders. In the current study, four groups of 2, 4-diamino-1, 3, 5-triazine derivatives were synthesized and investigated for their neuronal sodium channels binding activity. 5-Aryl-1, 3, 5-triazaspiro [5.5] undeca-1, 3- diene-2, 4-diamines (4a–4j) were found to have the best neuronal sodium binding activity ...