Journal of Alzheimer's Disease 2013-01-01

Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.

Jun Ding, Zhili He, Juan Ruan, Zilong Ma, Ying Liu, Chengxin Gong, Khalid Iqbal, Shenggang Sun, Honghui Chen

文献索引：J. Alzheimers Dis. 37(3) , 587-92, (2013)

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摘要

Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that has been fully studied for its structure, receptor, and signaling pathways and its multiplex effects on neural system, skeletal muscle, and weight control. Recent research demonstrates that CNTF also plays an important role in neurogenesis and the differentiation of neural stem cells. In this article, we summarize the general characteristics of CNTF and its function on neural stem cells, which could be a valuable therapeutic strategy in treating neurological disorders.