Neurodazine

更新时间：2024-01-02 22:20:55

Neurodazine结构式	常用名	Neurodazine	英文名	Neurodazine
	CAS号	937807-66-4	分子量	460.952
	密度	1.2±0.1 g/cm3	沸点	669.0±55.0 °C at 760 mmHg
	分子式	C₂₇H₂₁ClN₂O₃	熔点	N/A
	MSDS	中文版美版	闪点	358.4±31.5 °C
	符号	GHS05, GHS06	信号词	Danger

Neurodazine用途

Neurodazine 是一种咪唑类小分子,是多能干细胞神经发生的促进剂,通过激活 Wnt 和 Shh 信号通路促进神经发生。Neurodazine 选择性抑制 P19 细胞的星形胶质细胞分化。

英文名	2-[5-(3-chlorophenyl)furan-2-yl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
英文别名	更多

描述	Neurodazine 是一种咪唑类小分子,是多能干细胞神经发生的促进剂,通过激活 Wnt 和 Shh 信号通路促进神经发生。Neurodazine 选择性抑制 P19 细胞的星形胶质细胞分化。
相关类别	信号通路 >> 干细胞及 Wnt 通路 >> Hedgehog 信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号
参考文献	[1]. Kim GH, et al. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4. [2]. Halder D, et al. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37.

描述

相关类别

信号通路 >> 干细胞及 Wnt 通路 >> Hedgehog

信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号

参考文献

[1]. Kim GH, et al. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4.

[2]. Halder D, et al. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37.

密度	1.2±0.1 g/cm3
沸点	669.0±55.0 °C at 760 mmHg
分子式	C₂₇H₂₁ClN₂O₃
分子量	460.952
闪点	358.4±31.5 °C
精确质量	460.155365
PSA	56.37000
LogP	6.42
蒸汽压	0.0±2.0 mmHg at 25°C
折射率	1.613
储存条件	-20°C，密闭，干燥

符号	GHS05, GHS06
信号词	Danger
危害声明	H301-H318-H413
警示性声明	P280-P301 + P310-P305 + P351 + P338
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危险品运输编码	UN 2811 6.1 / PGIII

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1H-Imidazole, 2-[5-(3-chlorophenyl)tetrahydro-2-furanyl]-4,5-bis(4-methoxyphenyl)-

Neurodazine

2-[5-(3-Chlorophenyl)tetrahydro-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole