Synthesis of. alpha.-alkoxyacrylonitriles using substituted diethyl cyanomethylphosphonates

SE Dinizo, RW Freerksen, WE Pabst…

文献索引：Dinizo,S.E. et al. Journal of Organic Chemistry, 1976 , vol. 41, # 17 p. 2846 - 2849

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被引用次数: 41

摘要

To develop a general synthesis of a-alkoxyacrylonitriles 1 and a-thioalkoxyacrylonitriles 2 which would avoid these multistep sequences, we required a Wittig reagent which could introduce the a-alkoxyacrylonitrile or a-thioalkoxyacrylonitrile synthon in a single operation. In particular, we desired the phosphonate Wittig reagents7 3 which offer the distinct advantage over phosphorane Wittig reagents of providing water-soluble, phosphate by- ...