Synthesis, antitumor activity, and chemical properties of silaplatin and related platinum (II) and platinum (IV) complexes derived from. beta.-silyl amines

WK Anderson, R Kasliwal, DM Houston…

文献索引：Anderson, Wayne K.; Kasliwal, Ravindra; Houston, D. Michael; Wang, Yueh-sha; Narayanan, Ven L.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3789 - 3797

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被引用次数: 29

摘要

Platinum (11) and platinum (IV) coordination complexes derived from P-silyl-substituted amines were prepared. The solubility of selected complexes in water and physiological saline was measured, and the effect of the, &silicon on the reactivity of the complex in aqueous solution was determined by HPLC. The stabilities of selected silyl complexes were compared to the carbon analogues. The cyclic complexes 2a (“silaplatin”) and its Pt (IV) ...