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Bioorganic & Medicinal Chemistry Letters 2007-11-15

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.

Martijn Verdoes, Ulrik Hillaert, Bogdan I Florea, Myra Sae-Heng, Martijn D P Risseeuw, Dmitri V Filippov, Gijsbert A van der Marel, Herman S Overkleeft

文献索引:Bioorg. Med. Chem. Lett. 17(22) , 6169-71, (2007)

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摘要

The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.

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