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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

2-Acetylpyridine thiosemicarbazones. 8. Derivatives of 1-acetylisoquinoline as potential antimalarial agents

…, JP Scovill, J Bruce, JF Bartosevich

文献索引：Klayman; Scovill; Bruce; Bartosevich Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 84 - 87

全文：HTML全文

被引用次数: 34

摘要

A series of 1-acetylisoquinoline thiosemicarbazones was prepared in order to evaluate their antimalarial properties. This was achieved by the reaction of 1-acetylisoquinoline with methyl hydrazinecarbodithioate to give methyl 3-[1-(l-isoquinolinyl) ethylidene] hydrazinecarbodithioate (11). Displacement of the S-methyl group from this intermediate by various primary and secondary amines afforded the desired 1-acetylisoquinoline ...

N-甲基环己胺结构式

N-甲基环己胺

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

~65%

1-cyclohexyl-3-(1-isoquinolin-1-ylethylamino)-1-methyl-thiourea结构式

1-cyclohexyl-3-...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

1-cyclohexyl-3-(1-isoquinolin-1-ylethylamino)-1-methyl-thiourea结构式

1-cyclohexyl-3-...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~%

1-cyclohexyl-3-(1-isoquinolin-1-ylethylamino)-1-methyl-thiourea结构式

1-cyclohexyl-3-...

1-(2-吡啶基)哌嗪结构式

1-(2-吡啶基)哌嗪

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

~80%

N-(1-isoquinolin-1-ylethyl)-4-pyridin-2-yl-piperazine-1-carbothiohydrazide结构式

N-(1-isoquinoli...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

N-(1-isoquinolin-1-ylethyl)-4-pyridin-2-yl-piperazine-1-carbothiohydrazide结构式

N-(1-isoquinoli...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~%

N-(1-isoquinolin-1-ylethyl)-4-pyridin-2-yl-piperazine-1-carbothiohydrazide结构式

N-(1-isoquinoli...

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

3-氮杂双环(3.2.2)壬烷结构式

3-氮杂双环(3.2.2)壬烷

~72%

N-(1-isoquinolin-1-ylethyl)-3-azabicyclo[3.2.2]nonane-3-carbothiohydrazide结构式

N-(1-isoquinoli...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

N-(1-isoquinolin-1-ylethyl)-3-azabicyclo[3.2.2]nonane-3-carbothiohydrazide结构式

N-(1-isoquinoli...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~%

N-(1-isoquinolin-1-ylethyl)-3-azabicyclo[3.2.2]nonane-3-carbothiohydrazide结构式

N-(1-isoquinoli...

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

苄胺结构式

~68%

1-benzyl-3-(1-isoquinolin-1-ylethylamino)thiourea结构式

1-benzyl-3-(1-i...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

1-benzyl-3-(1-isoquinolin-1-ylethylamino)thiourea结构式

1-benzyl-3-(1-i...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~%

1-benzyl-3-(1-isoquinolin-1-ylethylamino)thiourea结构式

1-benzyl-3-(1-i...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~75%

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

N-(1-isoquinolin-1-ylethyl)-1-methylsulfanyl-methanethiohydrazide结构式

N-(1-isoquinoli...

二甲胺结构式

~51%

3-(1-isoquinolin-1-ylethylamino)-1,1-dimethylthiourea结构式

3-(1-isoquinoli...

1-乙酰基异喹啉结构式

1-乙酰基异喹啉

~%

3-(1-isoquinolin-1-ylethylamino)-1,1-dimethylthiourea结构式

3-(1-isoquinoli...

methyl 3-(1-(1-isoquinolinyl)ethylidene)hydrazinecarbodithioate结构式

methyl 3-(1-(1-...

~%

3-(1-isoquinolin-1-ylethylamino)-1,1-dimethylthiourea结构式

3-(1-isoquinoli...