| 常用名 | 鸦胆亭 | CAS号 | 41451-75-6 |
|---|---|---|---|
| 价格 | ¥1200.0/10mg ¥1800.0/20mg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 5 g |
| 产品详情(用途,包装等)
用途: Bruceantin(NSC165563) is first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.IC50 value:Target: anticancerCell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity. 物理化学性质: CAS号:41451-75-6 常用中文名:鸦胆亭 常用英文名:Bruceantin 分子式:C28H36O11 分子量:548.579 密度:1.4±0.1 g/cm3 沸点:731.0±60.0 °C at 760 mmHg 熔点:N/A 闪点:239.4±26.4 °C 储存条件:-20°C |