鸦胆亭

• 常用名: 鸦胆亭
• 英文名: Bruceantin
• CAS号: 41451-75-6
• 分子量: 548.579
• 密度: 1.4±0.1 g/cm3
• 沸点: 731.0±60.0 °C at 760 mmHg
• 分子式: C₂₈H₃₆O₁₁
• 熔点: N/A
• 闪点: 239.4±26.4 °C

鸦胆亭用途

Bruceantin(NSC165563)可从痢鸦胆子中提取,对B16黑色素瘤,结肠癌38,L1210和白血病P388有抑制性。

鸦胆亭名称

• 中文名: 鸦胆亭
• 英文名: Bruceantin
• 中文别名: 鸦胆停

鸦胆亭生物活性

• 描述: Bruceantin(NSC165563)可从痢鸦胆子中提取,对B16黑色素瘤,结肠癌38,L1210和白血病P388有抑制性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 其他
• 参考文献:

  [1]. Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.

  [2]. Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.

鸦胆亭物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 731.0±60.0 °C at 760 mmHg
• 分子式: C₂₈H₃₆O₁₁
• 分子量: 548.579
• 闪点: 239.4±26.4 °C
• 精确质量: 548.225769
• PSA: 165.89000
• LogP: 2.96
• InChIKey: IRQXZTBHNKVIRL-KPKJPENVSA-N
• SMILES: COC(=O)C12OCC34C(CC5C(C)=C(O)C(=O)CC5(C)C3C(O)C1O)OC(=O)C(OC(=O)C=C(C)C(C)C)C24
• 蒸汽压: 0.0±5.4 mmHg at 25°C
• 折射率: 1.598
• 储存条件: -20°C

鸦胆亭毒性和生态

鸦胆亭靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：Cytotoxicity against human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL955283

实验名称：qHTS drug screen for cell cycle checkpoint inhibitors in PARPi-resistant BRCA-mutant ... 来源：NCGC External Id：FGL-PARP_PEO-CTG96h-MIPE5.0-p1

实验名称：Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected h... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1019090

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

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鸦胆亭英文别名

• [11b,12a,15b(E)]-15-[(3,4-Dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxopicras-3-en-21-oic Acid Methyl Ester
• Methyl (11β,12α,15β)-15-{[(2E)-3,4-dimethyl-2-pentenoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate
• Methyl (11β,12α,15β)-15-{[(2E)-3,4-dimethylpent-2-enoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate