依西美坦
更新时间：2024-09-17 13:10:33
| 常用名 | 依西美坦 | CAS号 | 107868-30-4 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/10g | 纯度 | 99.0% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.Target: AromataseApproved: October 2005Exemestane competitively inhibits and time-dependently inactivates of human placental aromatase with Ki of 4.3 nM. Exemestane displaces [3H]DHT from rat prostate androgen receptor with IC50 of 0.9 μM [1]. Exemestane (1 μM) increases alkaline phosphatase activity in hFOB and Saos-2 cells and induces the expression of MYBL2, OSTM1, HOXD11, ADCYAP1R1, and glypican 2 in hFOB cells [2]. Exemestane causes aromatase degradation in a dose-responsive manner in MCF-7aro cells [3].Exemestane increases lumbar spine BMD by 14.0% in OVX rats at dose of 100 mg/kg. Exemestane (100 mg/kg) and 17-hydroexemestane (20 mg/kg) significantly reduces an ovariectomy-induced increase in serum pyridinoline and serum osteocalcin in rats and causes significant reductions of serum cholesterol and low-density lipoprotein cholesterol inOVX rats [4].Exemestane (20 mg/kg/day s.c.) induces 26% complete (CR) and 18% partial (PR) tumor regressions in rats with 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors [5]. 物理化学性质： CAS号：107868-30-4 常用中文名：依西美坦 常用英文名：Exemestane 分子式：C20H24O2 分子量：296.403 密度：1.1±0.1 g/cm3 沸点：453.7±45.0 °C at 760 mmHg 熔点：155.13°C 闪点：169.0±25.7 °C 储存条件：Store at -20°C |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：依西美坦
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Exemestane
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$66/10mM*1mLinDMSO