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科罗索酸

更新时间:2023-01-26 11:53:35

常用名 科罗索酸 CAS号 4547-24-4
价格 ¥800.0/20mg 纯度 98.0%
备货期 1天 库存 900 mg
 产品详情(用途,包装等)
用途:
Corosolic acid isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity.IC50 value: 26.8 μg/ml in vitroTarget:In vitro: Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay [1]. MTT method was used to detect the influence of corosolic acid on A549 lung cancer cell growth in vitro under different concentrations. The value of IC50 was 26.8 μg/ml in vitro experiment. Corosolic acid of different doses had certain therapeutic effects on A549 solid tumor, the content of VEGF and CD34 proteins also had different degrees of influence [2]. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. It inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells, decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1 [3]. In vivo: A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid.
物理化学性质:
CAS号:4547-24-4
常用中文名:科罗索酸
常用英文名:Corosolic acid
分子式:C30H48O4
分子量:472.700
密度:1.1±0.1 g/cm3
沸点:573.3±50.0 °C at 760 mmHg
熔点:N/A
闪点:314.6±26.6 °C
储存条件:2-8°C

供应商信息

上海源叶生物科技有限公司

认证状态:未认证供应商
电话:61559134
地址:上海市松江区长塔路465号6幢
地区: 上海市 上海市 松江区
联系人:何喜莲
联系人电话:15921386130 021-61559134
邮件:3285254746@qq.com
网址:http://www.shyuanye.com
主要市场:国内
年贸易额:¥1000万-5000万
外贸占销售比例:
主要合作伙伴:
上海源叶生物科技有限公司是一家专门从事生物技术相关产品研发和销售的综合性生命科学公司,在全体员工的不懈努力和广大客户的大力支持下,公司迅速成长为一家拥有生物试剂部、实验部、生命科学仪器部以及技术服务部等部门的高新技术企业。 公司地址:上海市杨浦区黄兴路1999号2号楼8E 我们的理念: 客户至上、服务至真;质量第一、诚信为本
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参考价格:$106/10mM*1mLinDMSO
其他供应商价格:
2024-07-15 科罗索酸
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2019-03-05 科罗索酸
价格:¥788.0
2021-02-06 Corosolic Acid
价格:¥2099.0
2024-03-12 科罗索酸
价格:¥360.9
2023-03-30 科罗索酸
价格:¥2000.0
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价格:¥需询单
2017-09-02 科罗索酸
价格:¥需询单
2018-07-12 科罗索酸
价格:¥2200.0

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