科罗索酸

Q: 科罗索酸的储存条件是什么？

科罗索酸储存条件：2-8°C。

Q: 科罗索酸的CAS号是多少？

科罗索酸CAS号为4547-24-4。

Q: 科罗索酸的外观是什么？

科罗索酸外观为细-棕色黄色粉末。

更新时间：2026-07-03 13:09:29

科罗索酸结构式	常用名	科罗索酸	英文名	Corosolic acid
	CAS号	4547-24-4	分子量	472.700
	密度	1.1±0.1 g/cm3	沸点	573.3±50.0 °C at 760 mmHg
	分子式	C₃₀H₄₈O₄	熔点	N/A
	MSDS	美版	闪点	314.6±26.6 °C

科罗索酸用途

科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

中文名	科罗索酸
英文名	Corosolic acid
中文别名	2-alpha-羟基熊果酸 \| 2Α-羟基熊果酸 \| 2-alpha-羟基熊果酸
英文别名	更多

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

描述	科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。
相关类别	信号通路 >> 自噬 >> 自噬研究领域 >> 癌症天然产物 >> 萜类化合物和糖苷
参考文献	[1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70. [2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08 [3]. Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14–723

描述

科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。

相关类别

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

参考文献

[1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70.

[2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08

[3]. Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14–723

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

密度	1.1±0.1 g/cm3
沸点	573.3±50.0 °C at 760 mmHg
分子式	C₃₀H₄₈O₄
分子量	472.700
闪点	314.6±26.6 °C
精确质量	472.355255
PSA	77.76000
LogP	7.82
InChIKey	HFGSQOYIOKBQOW-ZSDYHTTISA-N
SMILES	CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1C
外观性状	细-棕色黄色粉末
蒸汽压	0.0±3.6 mmHg at 25°C
折射率	1.567
储存条件	2-8°C

本表为化学品安全说明书MSDS数据，包含危险标识、成分、急救、消防、泄漏处置、操作储存等安全信息。

科罗索酸MSDS英文版

本表记录该化合物安全警示、防护措施、禁配物、处置方式等安全相关参考信息。

危险品运输编码	NONH for all modes of transport

本表提供该化合物公开报道的合成路线、反应条件、反应物与产物参考信息。

benzyl-2α,3β-di...

869788-73-8

~98%

科罗索酸

4547-24-4

查看详情

文献：Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Cheng, Keguang; Zhang, Pu; Zhang, Liying; Hao, Jia; Zhang, Luyong; Ni, Peizhou; Zographos, Spyros E.; Leonidas, Demettes D.; Alexacou, Kyra-Melinda; Gimisis, Thanasis; Hayes, Joseph M.; Oikonomakos, Nikos G. Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3540 - 3554

2,3-O-Diacetylc...

57498-76-7

科罗索酸

4547-24-4

查看详情

文献：Use- Techno Corporation Patent: US2005/137259 A1, 2005 ; Location in patent: Page/Page column 5 ;

熊果酸苄酯

869788-71-6

科罗索酸

4547-24-4

查看详情

文献：Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948

乌索酸苄酯

192211-41-9

科罗索酸

4547-24-4

查看详情

文献：Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948

benzyl (1S,2R,4...

869788-72-7

科罗索酸

4547-24-4

查看详情

文献：Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948

熊果酸

77-52-1

科罗索酸

4547-24-4

查看详情

文献：Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948

科罗索酸甲酯

4518-70-1

科罗索酸

4547-24-4

查看详情

文献：Das, Manik C.; Mahato, Shashi B. Phytochemistry (Elsevier), 1982 , vol. 21, # 8 p. 2069 - 2074

2-乙酰氧基科罗索酸

130289-37-1

科罗索酸

4547-24-4

查看详情

文献：Talapatra, Bani; Chaudhuri, Prabir K.; Mallik, Asok K.; Talapatra, Sunil K. Phytochemistry (Elsevier), 1983 , vol. 22, # 11 p. 2559 - 2562

2,3-BIS(ACETYLO...

14087-64-0

科罗索酸

4547-24-4

查看详情

文献：Glen,A.T. et al. Journal of the Chemical Society [Section] C: Organic, 1967 , vol. , p. 510 - 515

本表列出该化学品对应的上游起始原料以及下游衍生产物清单。

科罗索酸上游产品 8
CAS号57498-76-7 2,3-O-Diacetylc... CAS号869788-71-6 熊果酸苄酯 CAS号192211-41-9 乌索酸苄酯 CAS号869788-72-7 benzyl (1S,2R,4...
CAS号77-52-1 熊果酸 CAS号4518-70-1 科罗索酸甲酯 CAS号130289-37-1 2-乙酰氧基科罗索酸 CAS号14087-64-0 2,3-BIS(ACETYLO...
科罗索酸下游产品 1
CAS号130289-37-1 2-乙酰氧基科罗索酸

本表为该化合物相关公开文献，包含文献标题、期刊、发表信息等参考资料。

Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.

PLoS ONE 10 , e0137207, (2015)

To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects...

Simultaneous determination of five triterpene acids in rat plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic study after oral administration of Folium Eriobotryae effective fraction.

Biomed. Chromatogr. 29 , 1791-7, (2015)

Folium Eriobotryae effective fraction (FEA), the extract of Folium Eriobotryae, had been used as anti-hyperglycemia and anti-hyperlipemia medicine in China. A previous study indicated that euscaphic a...

Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway.

PLoS ONE 10 , e0126725, (2015)

Inhibition of VEGFR2 activity has been proposed as an important strategy for the clinical treatment of hepatocellular carcinoma (HCC). In this study, we identified corosolic acid (CA), which exists in...

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincu...
来源：ChEMBL
靶标：Ubiquitin carboxyl-terminal hydrolase 7
External Id：CHEMBL5234085

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
来源：Broad Institute
靶标：N/A
External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
来源：The Scripps Research Institute Molecular Screening Center
靶标：N/A
External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
来源：NCGC
靶标：N/A
External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
来源：Burnham Center for Chemical Genomics
靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

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本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

2-a-hydroxyursolic acid

hydroxyursolic acid

Corosolic acid

2,3-dihydroxyurs-12-en-28-oic acid

2alpha-hydroxyursolic acid

2α-Hydroxyursolic acid

MFCD03840521

(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 科罗索酸的LogP（油水分配系数）是多少？