科罗索酸

• 常用名: 科罗索酸
• 英文名: Corosolic acid
• CAS号: 4547-24-4
• 分子量: 472.700
• 密度: 1.1±0.1 g/cm3
• 沸点: 573.3±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₈O₄
• 熔点: N/A
• 闪点: 314.6±26.6 °C

科罗索酸用途

科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。

科罗索酸名称

• 中文名: 科罗索酸
• 英文名: Corosolic acid
• 中文别名: 2-alpha-羟基熊果酸 | 2Α-羟基熊果酸 | 2-alpha-羟基熊果酸

科罗索酸生物活性

• 描述: 科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 癌症
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70.

  [2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08

  [3]. Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14–723

科罗索酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 573.3±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₈O₄
• 分子量: 472.700
• 闪点: 314.6±26.6 °C
• 精确质量: 472.355255
• PSA: 77.76000
• LogP: 7.82
• InChIKey: HFGSQOYIOKBQOW-ZSDYHTTISA-N
• SMILES: CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1C
• 外观性状: 细-棕色黄色粉末
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 2-8°C

科罗索酸MSDS

科罗索酸MSDS英文版

科罗索酸安全信息

• 危险品运输编码: NONH for all modes of transport

科罗索酸靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincu... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 7 External Id：CHEMBL5234085

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

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科罗索酸英文别名

• 2-a-hydroxyursolic acid
• hydroxyursolic acid
• Corosolic acid
• 2,3-dihydroxyurs-12-en-28-oic acid
• 2alpha-hydroxyursolic acid
• 2α-Hydroxyursolic acid
• MFCD03840521
• (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid